How does enclomiphene citrate therapy work? A comprehensive guide

According to guys at PRCPB, enclomiphene citrate therapy is a quickly evolving medical treatment option for men looking to improve fertility. It is a synthetic form of the naturally occurring female hormone estrogen, and it works by blocking testosterone in the body while also stimulating the testicles to produce more sperm. This article provides an overview of enclomiphene citrate therapy, how it works and its potential benefits.

According to guys at PRCPB, Enclomiphene citrate is a nonsteroidal oral medication that is used primarily as an infertility treatment for men with low sperm counts or other reproductive issues. The active ingredient in enclomiphene citrate – clomiphene citrate – has been used effectively since 1971 to induce ovulation in women, but it has only recently been studied as a treatment option for men. In 2018, the FDA approved enclomiphene citrate therapy for use in male hypogonadism.

How Does Enclomiphene Citrate Work?

Enclomiphene citrate blocks testosterone production by preventing its release from Leydig cells in the testes while simultaneously stimulating the production of follicle-stimulating hormone (FSH) from pituitary gland cells. FSH helps regulate spermatogenesis, which is necessary for normal sperm production and fertility. By stimulating FSH while inhibiting testosterone, enclomiphene plays an important role in improving male fertility.

Benefits of Enclomiphene Citrate Therapy

The primary benefit of enclomiphene citrate therapy is improved fertility in men with reduced sperm count or quality due to hormonal imbalances or other health conditions such as polycystic ovarian syndrome (PCOS). Studies have shown that enclomopine can increase sperm counts up to threefold compared to baseline levels within just two months of treatment; this can lead to improved chances of conception if all other factors are favorable. Additionally, because it does not contain any hormones itself, there are fewer side effects associated with this type of treatment than with traditional hormone therapies like testosterone replacement therapy (TRT).

Risks Associated With Enclompiene Citrate Therapy

Despite its efficacy and relative safety profile when compared to TRT, there are still some risks associated with using enclompiene cirtate therapy, including increased risk of developing blood clots or stroke due to elevated estrogens levels caused by excessive FSH production stimulation. Additionally, long-term use may be linked with liver damage due higher concentrations circulating through the system over time; this risk can be minimized through regular monitoring and lifestyle modifications such as limiting alcohol consumption and exercising regularly during treatment periods.

Who Should Avoid Using Enclompiene Cirtate Therapy?

While generally safe and effective for many men who suffer from low sperm count or other reproductive issues caused by hormonal imbalances or PCOS, certain individuals should avoid using enclompiene cirtate therapy based on their individual health history or current medications they may be taking: those suffering from hepatic impairment or kidney disease should not use this medication; likewise anyone currently taking anticoagulants should consult their doctor before beginning any hormone therapy as these medications can interact negatively if taken together over long periods of time.


Overall, enclompiene cirtate therapy offers a viable solution for most men suffering from low semen parameters due to hormonal infertility problems such as PCOS. The benefits include improved fertility without major side effects; however, caution should be taken when considering long-term use given the potential risks associated with elevated levels of estrogen circulating through our system over time, so regular monitoring during the treatment period is recommended. In addition, individuals with chronic medical conditions should seek medical clearance before attempting any form of hormone manipulation.

Categorized as Health

By Valarie

Valarie Palacios, MS, MA, RD, RYT, CSCS is a principle nutritionist and adviser. She is a Registered Dietician and holds master’s degrees in both Nutrition and Exercise Physiology from Kent State University